Pharmaceutics, Free Full-Text
Por um escritor misterioso
Descrição
Labetalol is a drug that exhibits both alpha and beta-adrenergic receptor-blocking properties. The American Heart Association/American Stroke Association (AHA/ASA) has recommended labetalol as an initial treatment option for the management of severe hypertension. The physiologically based pharmacokinetic (PBPK) model is an in silico approach to determining the pharmacokinetics (PK) of a drug by incorporating blood flow and tissue composition of the organs. This study was conducted to evaluate the primary reasons for the difference in PK after intravenous (IV) and oral administration in healthy and diseased (renal and hepatic) populations. A comprehensive literature search was done using two databases, PubMed and Google Scholar. Various PK parameters were screened for the development of the PBPK model utilizing a population-based PK-Sim simulator. Simulations were performed after creating building blocks firstly in healthy individuals and then in diseased patients after IV and oral administration. The disposition of labetalol after IV and oral administration occurring in patients with the hepatic and renal disease was predicted. The model was evaluated by calculating the Robs/pred ratio and average fold error (AFE), which was in the two-fold error range. Moreover, Box-whisker plots were made to compare the overall concentration of the drug in the body at various stages of disease severity. The presented model provides useful quantitative estimates of drug dosing in patients fighting against severe chronic diseases.
MXenes and MXene-based materials for removal of pharmaceutical compounds from wastewater: Critical review - ScienceDirect
MedLine Pharmaceutical
Pharmaceutics, Free Full-Text
Exploring Trends and Opportunities in the Pharma Secondary Packaging Market for a Pharmaceutical Client, Infiniti's Latest FREE Downloadable Resource
Extemporaneous Compounding, PDF, Pharmaceutical Drug
Understanding Pharma: The Professional's Guide to How Pharmaceutical and Biotech Companies Really Work by John J. Campbell - Hardcover - 2008 - from Revaluation Books (SKU: __0976309637)
Archem Process Equipment Ltd.
Pharmacy - Wikipedia
Tivic Health Establishes Halal Compliance for ClearUP, FDA-Approved, Effective, Drug-Free Alternative for Sinus Pain, Pressure, and Congestion
Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection—Pharmaceutics
SOLUTION: Unit 1 pharmaceutics b pharmacy 1st sem - Studypool
CBD OIL - Compound Pharmaceutical Technologies
de
por adulto (o preço varia de acordo com o tamanho do grupo)
